Endocrine Abstracts

Introduction: Acromegaly is a chronic, slowly progressing disease caused in most cases by growth hormone (GH)- producing pituitary adenoma. This rare disorder is associated with a spectrum of various clinical manifestations and treatment outcomes differ between patients. The aim of this study was to evaluate the impact of adenoma size on comorbidities and biochemical status at the diagnosis of disease.Methods: This is a one-centre cohort study conducted ...

Background and Aims: Acromegaly is a rare condition caused by an excessive secretion of growth hormone (GH) and insulin-like growth factor1 (IGF-1), which are responsible for exaggerated somatic growth and distorted proportions. The objective of the current work was to investigate the clinical and demographic features of acromegaly in Mediterranean patients.Patients and Method: From 1997 to 2021, 29 patients with acromegaly were diagnosed and followed up...

Background and Aims: Acromegaly is an insidious disease related to hypersecretion of growth hormone (GH) that leads to several cardiovascular, respiratory, and metabolic comorbidities. The onset of dysmorphic body changes is one of the earliest signs of this condition. The objective of the current work was to describe the clinical manifestations of dysmorphic modifications characterizing Mediterranean patients diagnosed with acromegaly.Patients and Metho...

Introduction: Perrault syndrome (PS) is a rare disease characterized by the association of a premature ovarian failure (with primary or secondary amenorrhea) and a sensorineural deafness. In this context we report the case of three patients presenting the association of these two anomalies.Cases: We report the cases of three females, including two sisters from a consanguineous marriage, aged 21, 16 and 23 years, respectively. The two cardinal signs of th...

Introduction: Polyglandular autoimmune syndrome (PAS) are uncommon constellations of autoimmune diseases characterized by the occurrence of two or more auto-immune endocrine diseases in the same individual.Patients and methods: It is a case-control study about 108 cases for 120 healthy subjects recruited as the control group. We aimed to study the polymorphism of the HLA class-II genes of patients compared to that of healthy subjects so as to identify th...

Background and Aim: Diabetic neurogenic bladder (DNB) is a frequent complication affecting up to 45% of patients suffering from diabetes mellitus (DM). Our study aims to evaluate the impact of DNB on the quality of life (QoL) in this population.Patients and Methods: We conducted a descriptive cross-sectional study involving 200 patients with DNB. Their QoL was assessed using the Ditrovie scale.Results: The mean age was 59.3±10.6...

Objective: to analyze the dietary and metabolic factors predictive of the occurrence of pancreatitis in patients with type 1 diabetes mellitus (T1DM).Patients and Methods: Analytical case-control study of 31 T1DM patients separated into two subgroups: G1 (n=10): T1DM cases with pancreatitis. G2 (n=21): T1DM controls without pancreatitis.Results: The age at diagnosis of T1DM was comparable between the two groups. A...

Objective: To determine the influence of metabolic disturbances associated with diabetes mellitus (DM) on the clinical manifestations of the diabetic neurogenic bladder (DNB).Patients and Methods: Analytical cross-sectional study comparing two groups of patients suffering from DM: G1 (n=159) with manifestations of DNB versus G2 (n=41) without signs of DNB.Results: G2 patients were younger than G1 patients (58±1...

Objective: To describe the etiological profile the outcomes of acute pancreatitis (AP) in patients with type 1 diabetes (T1DM).Patients and Methods: A retrospective descriptive study of 10 T1DM patients who presented at least one episode of AP during their follow-up.Results: The mean age at diagnosis of T1DM was 19.7±9.3 years, with a female predominance (60%). T1DM was frequently inaugurated by a cardinal syndrome (50%) or spon...

Introduction: Anemia is defined by the World Health Organization as a hemoglobin concentration less than 120 g/l in women outside of pregnancy, and less than 130 g/l in men over 15 years of age. It is common in diabetics. It can be due to an autoimmune disease associated with type 1 diabetes, whereas the inflammatory cause is the primary cause in type 2 diabetes.Observation: This is a 75 year old patient, type 2 diabetic for 21 years on insulin analogues...